JUN and breast carcinoma: According to Kim et al., treatment with 70% ethanol extract of S. miltiorrhiza inhibited matrix metalloproteinase (MMP)-9 expression and cell invasion in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MCF-7 breast cancer cells, possibly through down-regulating the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway [30].