VEGFA and non-small cell lung carcinoma: Lee et al. demonstrated that the arsenic herbal mixture PROS (tetraarsenic hexoxide [PR] + Olendlandia diffusa and Salvia miltiorrhiza extract (5:2) [OS]) showed apoptotic and anti-angiogenic effects in non-small-cell lung cancer cells (NSCLCs) via inhibition of signal transducer and activator of transcription 3 (STAT3)/vascular endothelial growth factor (VEGF)/cyclin-dependent kinase 2 axis signaling [35].