FOS and breast carcinoma: According to Kim et al., treatment with S. miltiorrhiza extract at a dose of 50 μg/mL for 24 h specifically inhibited the MAPK/AP-1 signaling pathway in TPA-induced breast cancer cells and did not influence the phosphorylation of inhibitory κ B kinase (IKK) α/β and IκBα subunit, degradation of IκBα, or nuclear translocation of NF-κB p65 [30].