AKT1 and non-small cell lung carcinoma: According to Ye et al., methanol extract of S. miltiorrhiza could inhibit the growth of non-small cell lung cancer (NSCLC) via induction of apoptosis through mitochondrial apoptotic pathway and phosphatase and tensin homolog (PTEN)-mediated inhibition of the phosphoinositide 3 kinase (PI3K)/Akt pathway [34].