In vivo S. miltiorrhiza extract administration for 4 weeks also down-regulated hepatic protein expression of TNF-α and COL I and mRNA expression of NASH-related specific genes such as TNF-α, TGF-β1, IL-1β, C-reactive protein (CRP), α-SMA, COL I, MMP-2, MMP-9. This evidence concerns the gene CRP and metabolic dysfunction-associated steatohepatitis.