BCL2 and neoplasm: In vivo, BALB/c NU mice xenografted with HSC-3 tumor were intraperitoneally injected with 50 or 100 mg/kg of S. miltiorrhiza extract for 34 days, which resulted in the suppression of tumor growth without any significant impacts on mouse body weights; as for biological markers, treatment with S. miltiorrhiza extract led to decreased expression of XIAP and survivin but not Bcl-2 family members.