TIMP1 and Hepatic fibrosis: For example, the anti-fibrotic effect of S. miltiorrhiza extract in a mouse model of thioacetamide-induced liver fibrosis was demonstrated in Parajuli et al.’s study, where S. miltiorrhiza extract administration at doses of 1 or 2.5 mg/kg for 12 weeks reduced fibrous tissue deposition and down-regulated the expression of central markers of fibrosis including COL I, TIMP-1, and α-SMA [71].