In vivo administration of SCE also had an inhibitory effect on the mRNA expression levels of fibrosis-related genes, such as collagen type I alpha 1 (Col1a1), collagen type III alpha 1 (Col3a1), actin alpha 2 (Acta2), and the expression levels of the proteins encoded by these genes, including type I collagen (COL I), COL III, and α-smooth muscle actin (SMA), respectively, which indicated SCE-induced attenuation of myocardial fibrosis in mice after MI. Here, COL3A1 is linked to myocardial infarction.