Further elucidating the mechanism of BMP-2, Knockouts (KOs) and conditional KOs of BMP-2 in mice led to lethality or underdeveloped bones with reduced radial bone thickness, strength, and increased risk of spontaneous fractures; further, these KOs presented heart deficiencies, chondrocyte abnormalities, and reduced vasculature [14,32,34,35,36,37]. Here, BMP2 is linked to hyperinsulinemic hypoglycemia, familial, 4.