Angiogenesis score high-tumor significantly enriched not only immune-related pathways, but also inflammation-related pathways such as inflammatory response, IL6, TNFα signaling, TGFβ signaling, as well as metastasis-related gene pathways including EMT, and Hedgehog-, notch- and WNT-β catenin-signaling. The gene discussed is IL6; the disease is neoplasm.