Although the number of clinical trials for the development of therapeutics including chemotherapy (cyclophosphamide), immunomodulating monoclonal antibodies therapies (anti-PD-1/PD-L1 and anti-CTLA4), and small molecule-targeted therapies (BRAF inhibitor) for melanoma treatment is increasing every year [24], canonical Wnt signaling-targeted therapy is not registered for melanoma therapy. The gene discussed is CD274; the disease is melanoma.