In this study, two different CRC cell lines, namely non-metastatic CaCo-2 cells and metastatic SW620 cells, were selected, and the corresponding exosomes were extracted from their cell culture medium to investigate possible exosomes mediated modifications that could be induced on normal colon epithelial cells (HCEC-1CT) in terms of migration ability and expression of FZD10, c-Myc and EMT markers. The gene discussed is FZD10; the disease is colorectal carcinoma.