After assessing the early activation of c-Myc protein, vimentin and FZD10 during treatment with tumor-derived exosomes, the expression of other proteins involved in EMT, such as N-cadherin, E-cadherin, b-catenin and Slug/Snail, combined with vimentin and FZD10, was evaluated by immunofluorescence analysis at long exposure times, namely at 3, 7 and 12 days. This evidence concerns the gene CDH2 and neoplasm.