The results of the performed investigation suggests that FZD10, a membrane receptor mediating the activation of the canonical pathway of Wnt and delivered by circulating tumor-derived exosomes, can represent a relevant player in promoting the CRC propagation, with autocrine and paracrine action and also above all in the metastatic sites, in the context of colorectal carcinogenesis. The gene discussed is FZD10; the disease is neoplasm.