MAPK3 and metabolic dysfunction-associated steatotic liver disease: Studies depict that miR-21 promotes hepatic lipid accumulation and modulates extracellular signal-regulated kinase 1 (ERK1) signaling and epithelial-mesenchymal transition in liver fibrosis, and hence it is found to be upregulated in serum and hepatic tissues of individuals with different stages of NAFLD [105,106].