Consequently, the plasma adiponectin levels showed a significant inverse correlation with the expression of miR-122 (r = −0.5175) (Figure 5A), miR-34a (−0.5498) (Figure 5B), miR-375 (−0.5871) (Figure 5C), miR-16 (−0.4419) (Figure 5D) and miR-21 (r = −0.5488) (Figure 5E), as the disease advances from obesity to diabetes causing fatty infiltration, which may further progress to severe form of NASH. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.