TGFB1 and Hepatic fibrosis: Furthermore, miR-16 dysregulation promote liver fibrosis in hepatic stellate cells by upregulating guanine nucleotide-binding α-subunit 12 (Gα12) mediated pro-fibrogenic signaling that in turn stimulate hepatic stellate cells activation through autophagy-mediated breakthrough of lipid droplets and possess a positive effect on TGF-β/Smad signaling pathway [102,103,104].