CCND1 and neoplasm: This finding was confirmed in mice xenografted with PC-3 cells, where RSV (30 mg/kg) administered through gavage alone or in combination with TRAIL inhibited tumor growth and angiogenesis; upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5, BAX, and p27; and inhibited the expression of Bcl-2 and cyclin D1 [158].