Examples of secondary CoQ10 deficiency resulting from such genes include mutations in the APTX gene encoding the protein aprataxin in ataxia oculomotor aprataxin 1 disorder [37], and the BRAF gene encoding the enzyme serine/threonine-protein kinase B-Raf in cardiofaciocutaneous syndrome [38], multiple acyl-CoA dehydrogenase deficiency (by mutations in the ETFDH gene; [39]) and spinocerebellar ataxia-10 (by mutations in the AN010 gene; [40]). The gene discussed is APTX; the disease is coenzyme Q10 deficiency.