HBB and thalassemia: On average, for HBBIVSI−110-homozygous cultures the functional HBB mRNA level was 37.2% × 2.06 ±1 and the HBB protein level 23.16 ± 6.78% of that observed for normal cultures (mRNA: 100% × 1.44 ±1; Protein: 100 ± 20.25%), showing only moderate correlation of mRNA and protein levels for HBBIVSI−110 thalassemia (Pearson correlation coefficient r = 0.494 of functional HBB mRNA vs. HBB protein levels, p = 0.213) across all samples.