Experiments with in vitro and in vivo models of patient-derived CRC revealed that HIF-1α and CAFs-secreted TGF-β synergistically induced the expression of the hedgehog transcription factor GLI2 (glioma-associated oncogene homolog 2), leading to 5-FU/oxaliplatin resistance [201]. The gene discussed is HIF1A; the disease is colorectal carcinoma.