Reactivity against multiple antigens was rare and only occurred in Sjögren’s syndrome (n = 1; anti-Ks and anti-Zoα), ASS (n = 1; anti-cN1A and anti-Zoα) and unclassifiable IIP (n = 1; anti-Ha, anti-Ks and anti-Zoα). The gene discussed is NT5C1A; the disease is Sjogren syndrome.