Besides, TH2 inflammation has been also strongly associated with type I hypersensitivity allergy (which is mediated by IgE) and eosinophilic inflammation [5,37], which can explain the higher levels of total serum IgE (median 462.0 vs. 137.9 UI/mL, p-value = 0.013) and blood eosinophils (median 500.0 vs. 300.0 cells/mm3, p-value = 0.002) in this population when compared with the Canary Islands patients. This evidence concerns the gene IGHE and inflammation.