In addition, since this threonine is also associated with the binding of drugs strongly effective against pancreatic cancer in mice [23,32], we hypothesize that the molecular effects of such drugs could be the induction of a stable fold (turn-like) by this polypeptide region, besides competitive steric hindrance, preventing binding to other natural partners of NUPR1, and hampering the protein cascades where it is involved. Here, NUPR1 is linked to pancreatic neoplasm.