Conversely, still in standard condition, MuRF1/MuRF3 double KO (M1/M3 dKO) mice undergo skeletal muscle myopathy and hypertrophic cardiomyopathy associated with less mobility, and walking and climbing impairment compared with WT and MuRF single mutants [129]. Here, TRIM63 is linked to hypertrophic cardiomyopathy.