When human endometrial Ishikawa cells and epithelial ECC-1 cells from endometrial adenocarcinoma were treated with LIF, higher expression levels of ITGAV, ITGB3 and ITGB5 adhesion molecules were observed; these are required for attachment of the embryo trophoblast to the receptive endometrial surface [47]. Here, LIF is linked to endometrium adenocarcinoma.