Both BACE-1 and GSK-3β are key targets for AD drug development and the first class of dual-target compounds that inhibit both enzymes, 6-amino-4-phenyl-3,4-dihydro-1,3,5-triazin-2(1H)-ones emerged through a ligand-based strategy [107,108]. The gene discussed is BACE1; the disease is Alzheimer disease.