Univariate analysis extracted age > 70 (HR 2.30, p < 0.001), male sex (HR 1.67, p = 0.034), cirrhosis (HR 3.56, p < 0.001), treatment-experienced (HR 1.82, p = 0.016), serum albumin < 3.5 g/dL at 12 weeks after the end of treatment (pw12) (HR 2.86, p = 0.007), and AFP > 7 ng/mL at pw12 (HR 6.17, p < 0.001) as associated with HCC. This evidence concerns the gene ALB and Cirrhosis.