As shown Figure 2A, the hazard ratio of ATP8A1, ACACB, A2G2D, SMPD3, LPIN1, FUT2, CD38, ST6GALNAC1, GATM, and EPHX3 was less than 1, indicating they were protective genes for HNSCC. The gene discussed is LPIN1; the disease is head and neck squamous cell carcinoma.