The hazard ratio of TXNRD1, ARSI, DHCR7, NUDT11, ARSJ, ASNS, ADA, AGPAT4, FKBP14, P4HA1, and MTHFD2 was larger than 1, suggesting that they were risky genes for HNSCC. This evidence concerns the gene TXNRD1 and head and neck squamous cell carcinoma.