The hazard ratio of TXNRD1, ARSI, DHCR7, NUDT11, ARSJ, ASNS, ADA, AGPAT4, FKBP14, P4HA1, and MTHFD2 was larger than 1, suggesting that they were risky genes for HNSCC. Here, MTHFD2 is linked to head and neck squamous cell carcinoma.