In addition, a number of in vivo studies have demonstrated that p53-dependent apoptosis or proliferation defects is profoundly involved in microcephaly caused by removal or mutation of a variety of molecules in mouse CNS (Table 1), including DNA damage repair protein NBN1 [36], the scaffold protein NDE1 [37], centrosomal protein CEP63 [38], tubulin TUBB5 [39], RNA metabolism protein EIF4A3 [40], RNA binding protein RBM8A [40], spliceosome component protein MAGOH [40], citron kinase protein CITK [41], or kinesin-like protein KIF20B [42]. Here, TP53 is linked to microcephaly.