In fact, when p53Y236delta (deletion of p53 codon 236) was transduced into the p53+/− or p53−/− primary neuroectodermal cells, which were subsequently transplanted into the brain of the adult WT mice, the presence of Y236delta in transplanted p53−/− cells had no effect on the tumor frequency and did not affect the tumor latency regardless of the genotype of the transplant. Here, TP53 is linked to neoplasm.