In addition, mice bearing a mutant p53 that disrupts Mdm2-p53 interaction and compromises p53 trans-activity, along with the wild-type (WT) p53 allele, showed late-gestational embryonic lethality associated with a host of developmental phenotypes characteristic of CHARGE (ocular coloboma, heart defects, choanal atresia, retarded growth, and development, genitourinary hypoplasia, and ear abnormalities) phenotypes [12]. This evidence concerns the gene TP53 and coloboma.