MDM2 and glioblastoma: A large number of molecules including those that inhibit Mdm2/p53 complex (such as Mdm2 inhibitors AMG232 and RG7112), restore WT p53 structure (such as PRIMA-1 and its analog) and degrade mutant p53 (such as HDAC inhibitors) showed promising outcomes on GBM cells or mouse models and have been discussed previously [60].