Moreover, low levels of miR-200c and miR-141 have been associated with increased drug resistance of pancreatic adenocarcinoma and the basal type of breast cancer, via induction of the EMT marker ZEB-ZEB-1 and, in turn, promotes the transcriptional activation of Notch, through regulation of Jagged-1 and Maml1 and 2 promoter binding activities [22,89,112]. This evidence concerns the gene ZEB1 and breast carcinoma.