CLN5 and hepatocellular carcinoma: On the same context, miR-148a downregulation, observed in a clinically aggressive stem-cell-like subtype of hepatocellular carcinoma (HCC), was associated with direct suppression of a type I receptor of Bone Morphogenetic Proteins (BMPs), namely Activin A Receptor Type 1 (ACVR1), which, in turn, results in inhibition of BMP/Wnt signaling [94].