As an example, in an inflammatory niche, the tumor-associated macrophages (TAMs) and CD4+ T cells stimulate the release of TNPα, which, in turn, activates NF-κB signaling and the downstream targets Slug, Snail, and Twist, resulting in induction of the epithelial-mesenchymal transition (EMT), and CSC invasion and migration to distant locations [1]. The gene discussed is TWIST1; the disease is neoplasm.