MiR-589-5p promotes the spheroid formation of CD133+ hepatocellular carcinoma (HCC) cells and their tumorigenicity in vivo by targeting the IL-6 pathway inhibitors SOCS2/5 and PTPNI/11, while it further accelerates tumor chemoresistance via regulation of Stat3 signaling [77]. The gene discussed is SOCS2; the disease is hepatocellular carcinoma.