H19 and neoplasm: As an example, the available data on HOTAIR and H19, two of the most well-studied lncRNAs in human malignancies, whose levels have been directly correlated with tumor stage and overall patient survival, are still in their infancy, as it relates to their regulation at multiple levels, their multifaceted actions in tumor initiation and progression, as well as their candidacy as putative biomarkers for cancer diagnosis, prognosis, and therapeutic targeting [231].