Two polymorphisms in the MIF gene regulatory region, a CATT5-7 microsatellite repeat (rs3063368) and a -270 (formerly described as -173) G>C single-nucleotide polymorphism (rs755622), which is in linkage disequilibrium with CATT7, have been studied regarding their association with different pathologic conditions (e.g., pulmonary tuberculosis, acute coronary syndrome, carotid artery atherosclerosis, systemic lupus erythematosis, multiple sclerosis) [8,14,25,26,27,28]. Here, MIF is linked to multiple sclerosis.