As reported in Figure 5D–E, Jagged1 and Jagged2 expressed in the MM cells correlated with the HES6 expression in non-tumor cells (r = 0.5673 and r = 0.5516, respectively), confirming a role of MM cell-derived Jagged in activating the Notch signaling in stromal cells. Here, JAG1 is linked to neoplasm.