Interestingly, MYC was also reported to have a role in promoting glutamine synthesis in a context of glutamine deprivation: in vitro and in vivo experiments on breast cancer cell lines revealed that MYC induces the expression of glutamine synthetase, resulting in increased glutamine synthesis, glutamine-mediated leucine uptake, survival in glutamine-deprived medium, and tumorigenesis [59]. This evidence concerns the gene MYC and breast carcinoma.