In particular, pancreatic ductal carcinoma cells exposed to the EMT-inducers Tumor Necrosis Factor α (TNFα) and TGFβ upregulate the expression of glucose transporters GLUT1 and GLUT 3 and the expression of several glycolytic enzymes (i.e., HK2, PKM2, LDH-A, and LDH-B) [147]. The gene discussed is TNF; the disease is pancreatic ductal adenocarcinoma.