The ethyl acetate extract of A. camphorata was shown to induce the activation of calpain-3 (CAPN-3) and caspases-12 (CASP-12) by increasing the level of Ca2+ in the cytoplasm of Hep3B cells and further induced the apoptosis of hepatoma cells [23]. Here, CASP12 is linked to hepatocellular carcinoma.