Similarly, others have shown that chronic myeloid leukemia (CML) cell line LAMA84-derived exosomes promote proliferation genes (BCL-xl, BCL-w, survivin) and downregulate pro-apoptotic genes such as BAD, BAX, and PUMA [34]. The gene discussed is BCL2L1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.