PRMT1 and digestive system neoplasm: Previously, Mathioudaki et al. [56] evaluated the expression pattern of alternative splicing variants of PRMT1, demonstrating that colon carcinogenesis and CRC aggressiveness is associated with a specific PRMT1 variant, denoted v1. The primer pair used here was not variant-specific and allowed for the amplification of v1-v4 isoforms of PRMT1, thus reflecting rather global PRMT1 expression, which may explain the lack of association with CRC pathological data.