These results suggest that amplification of 8q24 locus has a double impact on TRIB1 gene expression: (1) through the increase of its gene dosage and (2) through the upregulation of its upstream transcriptional activator cMYC. These data might explain the predominant overexpression of TRIB1 among 8q24 genes in our PCa analysis. The gene discussed is MYC; the disease is posterior cortical atrophy.