TRIB1 and posterior cortical atrophy: By taking advantage of a genetic setting of PCa susceptibility in mice (prostate-specific Pten heterozygosity) [59], we demonstrated that transgenic Trib1 expression elicits a substantial increase in the incidence of PCa, thus providing unprecedented evidence in genetically engineered mouse models, to support the causal contribution of this pseudokinase to prostate tumorigenesis.