BRCA1 and breast carcinoma: For instance, highly invasive breast cancer cells overexpress eIF4G1, a key factor in the eIF4F complex, and this overexpression was shown to be required for radioresistance to selectively promote translation of mRNAs involved in DNA repair and survival, such as ATM, ATR, p53, 53BP1, MRE11, GADD45α, XIAP, BRCA1/2, Survivin, ATRIP, CHK1, PARP, RFC2-5 and HIF-1α [125].