CREBBP and alcohol abuse: Separate from these pathways and studies, other studies have suggested alcohol-related roles of other genes in the network, including the cAMP-dependent protein kinase A (PKA) [114,197,201], protein kinase C (PKC) [79,202,203,204], CREB [205,206,207], and CREB binding protein (CBP) [117,208], consistently suggesting a causal role of cAMP signaling pathways in alcohol abuse.