The overexpression of TTP in hepatoma cells has been shown to decrease cell migration, thus supporting the potential tumor-suppressive function for this AUBP [86], whereas RBM38 has been reported to downregulate the migration/invasion of HepG2 cells by affecting the stability of the MDM2 mRNA and p53 signaling [125]. The gene discussed is TP53; the disease is hepatocellular carcinoma.