MAT1A and hepatocellular carcinoma: MAT1A is a potent apoptosis inducer, as its forced expression in human HCC cells increases the expression of various proapoptotic genes (e.g., ARH1, FRZB, and PP2A), while reducing the activity of prosurvival pathways (i.e., ERK and PI3K/AKT signaling) and hepatic tumorigenesis in mice [159].