SIRT2 and acute kidney injury: Consistent with observations in AKI, pharmacological inhibition of SIRT2 resulted in reduction of renal interstitial fibrosis in UUO models [148,149], which was accompanied by decreases in expression of epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor-β (PDGFR-β), STAT3 [148], and E3-ubiquitin ligase murine double-minute 2 (MDM2) [149].