SIRT1 up-regulation by resveratrol treatment ameliorated renal fibrosis in proximal tubular cells treated with TGF-β in addition to a mouse model of UUO; this was found to be due to inhibition of the EMT through deacetylation of Smad4 and inhibition of matrix metalloproteinase-7 (MMP-7) [147]. The gene discussed is TGFB1; the disease is renal fibrosis.