SIRT5 and kidney injury: A recent study reported that SIRT5 was highly expressed in both the mitochondria and peroxisomes of proximal tubular cells, but the opposite trend was observed in I/R-induced kidney injury compared to other types of sirtuins, as the loss of SIRT5 function led to renoprotective effects after I/R injury; shifting of fatty acid oxidation from the mitochondria to the peroxisome under the control of SIRT5 was suggested as the underlying mechanism.