In contrast to SIRT1, SIRT3, and SIRT6, the absence of SIRT2 and SIRT7, not their overexpression, significantly ameliorated cisplatin-induced AKI by decreasing inflammation and apoptosis through modulation of p38 and c-Jun N-terminal kinase (JNK) [79,90]. This evidence concerns the gene SIRT2 and acute kidney injury.