In contrast to SIRT1, SIRT3, and SIRT6, the absence of SIRT2 and SIRT7, not their overexpression, significantly ameliorated cisplatin-induced AKI by decreasing inflammation and apoptosis through modulation of p38 and c-Jun N-terminal kinase (JNK) [79,90]. Here, SIRT3 is linked to acute kidney injury.