The overexpression of miR-146a in the intestinal epithelial cells to response to the bacterial antigenslike lipopolysaccharide (LPS) or cytokines depends on the activation of the TLR4/MyD88/NF-kB, can induces immune tolerance and inhibits cytokine production in response to LPS and IL-1β in intestinal epithelial cells in the mouse model with colitis. This evidence concerns the gene MYD88 and colitis.