AKT1 and medullary thyroid gland carcinoma: Several previous studies have already proven that miR-375 is indeed upregulated in MTC, indicating that it might play a central role in the tumorigenesis of MTC, via targeting multiple crucial pathways, mainly the phosphatidylinositol 3-kinase/ serine/threonine protein kinase B (PI3K/Akt) pathway [101].