In a rat model of hypercholesterolemia, the introduction of H. elongata to pork meat was able to reduce the plasma cholesterol levels by upregulating glutathione reductase (GR); superoxide dismutase (SOD); and CYP7A1, which is involved in cholesterol metabolism, and downregulating catalase (CAT) and glutathione peroxidase (GPx), finally exerting anti-oxidant and hypocholesterolemic effects [133]. This evidence concerns the gene SOD1 and familial hypercholesterolemia.