It is conceivable that one or more subsets of acinar cells might be endowed with superior tumor-initiation capacity; for example, FACS-sorted Doublecortin-like Kinase 1 (Dlck1)-expressing acinar cells (represent 0.1–0.5% of the exocrine pancreas) more potently generate duct-like spheres in vitro [124]. Here, DCLK1 is linked to neoplasm.