Myo-Inositol (MI) was demonstrated to exert beneficial effects on overweight/obese women with polycystic ovary syndrome (PCOS), being able to increase mature oocytes yield, oocyte nuclear and cytoplasmic maturation, and finally embryo development [11,39], probably due to its capacity to provide metabolites able to mediate insulin action [40]. The gene discussed is INS; the disease is polycystic ovary syndrome.