Since the prostate tissue of patients with T2D AKR1C1, C2, and C3 transcripts showed positive associations with proliferative, HIF1α, and NFκB genes, our results suggest that in the prostate gland, AKR1C enzymes could be involved in the induction of inflammatory processes induced by diabetes. The gene discussed is AKR1C1; the disease is type 2 diabetes mellitus.