MUC5AC and malignant colon neoplasm: Furthermore, the changes in gene expression observed in the intestine would support such a hypothesis as transcripts of Muc2, the predominant secreted mucin from the ileum and colon, were increased (Velcich et al., 2002), and Muc2 deficiency in mice is associated with disruption of epithelial homeostasis and the development of colon cancer (Hsu et al., 2017).