Many factors, such as chemokine ligand 5, C-X-C motif chemokine 12, transforming growth factor β, insulin-like growth factors (IGF), epidermal growth factors (EGF), fibroblast growth factors (FGF), interleukin (IL)6, IL8, IL10, and IL11, secreted by CAFs have an essential role in regulating cancer development.26 Here, CXCL8 is linked to cancer.