IGF1 and cancer: Many factors, such as chemokine ligand 5, C-X-C motif chemokine 12, transforming growth factor β, insulin-like growth factors (IGF), epidermal growth factors (EGF), fibroblast growth factors (FGF), interleukin (IL)6, IL8, IL10, and IL11, secreted by CAFs have an essential role in regulating cancer development.26