IL10 and neoplasm: Consistent with this view, Tan et al. [147] have shown that depletion of MDSCs, particularly IL-10-producing PMN-MDSCs, which can inhibit DCs that activate anti-tumour cytotoxic T cell responses, can enhance the therapeutic efficacy of modified vaccinia Tiantan strain by inducing anti-tumour cytotoxic T cell responses in mesothelioma.