As such, it is not surprising that several studies have also documented that normal monocytes from healthy individuals can acquire the phenotype and the suppressive activity of M-MDSCs upon exposure to tumour cells or a specific microenvironment where certain cytokines such as IL-10, or prostaglandin E2 ‘PGE2' play a role in this transition [66–69]. The gene discussed is IL10; the disease is neoplasm.