IL10 and neoplasm: To further support the importance of IL-10 in immunosuppression mediated by MDSCs, another study showed that MDSCs isolated from histone-deacetylase 11 (a negative regulator of IL-10 transcription in myeloid cells of both humans and mice) knock-out tumour-bearing mice express more immunosuppressive effects and were able to secrete greater amounts of IL-10 than that of the ‘wild type' tumour-bearing mice [100].