CYP3A4 and hepatocellular carcinoma: Among these genes, CYP3A4, which is highlighted in the KEGG pathway, played an important role in the carcinogenesis process of HCC by promoting the transformation from aflatoxin B1 to AFB1‐exo‐8,9‐epoxide, consistent with Bonomo et al.48There is a consensus that AFB1,49 the most powerful carcinogen to date, works as a trigger in the carcinogenesis of the liver.