To further investigate the role of LMP in NPC disease pathogenesis, we used control (Ctrl) fibroblasts homozygous for WT NPC1 and NPC human fibroblasts homozygous for I1061T NPC1 (I1061T), the most common disease-causing allele in patients of Western European ancestry (24). The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.