NFKB1 and Alzheimer disease: In similar fashion, tetrandrine (a bisbenzylisoquinoline alkaloid isolated from Radix Stephania tetrandra) has shown promising NF-κB-mediated anti-inflammatory activity in BV-2 microglia activated with fibrillar amyloid beta and reduced hippocampal neuroinflammation by inhibiting NF-κB activation in a rat model of AD induced by amyloid beta (He et al. 2011a, b).