On the other hand, plasma levels of LPS binding protein are increased in obesity and T2D, demonstrating a positive correlation with BMI (Sato et al., 2014); CD14 expression is enhanced in obese humans (Fernández-Real et al., 2011), and the serum levels of haptoglobin are increased both in diabetic rats (Jelena et al., 2013) and in T2D patients (McMillan, 1989). This evidence concerns the gene HP and type 2 diabetes mellitus.