The impaired exercise capacity observed in skeletal muscle Lrrc8a KO mice are consistent with some level of insulin resistance, as in db/db mice (Ostler et al., 2014) and in humans (Reusch et al., 2013), and may be due to impaired skeletal muscle glycolysis and oxygen consumption in LRRC8A-depleted skeletal muscle. The gene discussed is LRRC8A; the disease is Insulin resistance.