MAPT and epilepsy: Tau hyper-phosphorylation is a pathological feature observed in brain samples from epileptic patients (Sen et al. 2007; Puvenna et al. 2016; Liu et al. 2017) and its pharmacological manipulation provided anti-seizure effects in several chronic acquired models of epilepsy (Tian et al. 2010; Jones et al. 2012; Garg et al. 2018).