CD34 and breast carcinoma: These models include bladder cancer humanized mouse models using NSG mice injected with CD34+ hematopoietic cells, breast cancer models created with NSG mice intrahepatically engrafted with breast carcinoma cell lines and engrafted with functional human immune systems, and CRC models via Rag2−/−yc−/− mice injected with human PBMC’s and subcutaneously engrafted on the flank with CRC cell line HT-29 [171, 172].