LGALS3 and osteosarcoma: Osteosarcoma cells are capable of secreting Gal-3 [9], and tumor-secreted Gal-3 influences osteoblasts and osteoclasts; Gal-3 inhibits osteoblast differentiation by Notch signaling activation [10] and mediates osteoclast fusion by interaction with Myosin-2A, a modulator of osteoclast differentiation, accelerating osteolytic bone remodeling [11].