Lung adenocarcinoma (LUAD) is one of the most benefitted cancers in the era of cancer immunotherapy according to several landmark clinical trials supporting the use of immune checkpoint blockades (ICB), anti-programmed cell death 1 (PD-1) antibody and anti-programmed cell death ligand 1 (PD-L1) antibody 1-3. Here, CD274 is linked to lung adenocarcinoma.