First, DSCAM-AS1 was previously reported to be regulated by ERα 22, 23, 62, 63, and FOXA1 and ERα usually bind together to regulate their target genes in breast cancer, so the dominant expression of DSCAM-AS1 in ER+ breast cancer may be caused by cooperative regulation of FOXA1 and ERα. This evidence concerns the gene ESR1 and breast carcinoma.